The Lin Lab applies biochemical knowledge and engineering principles to the development of protein-based tools for molecular imaging, optogenetic studies, and gene therapy. Topics of investigation include fluorescent protein structures and biophysics, fluorescent protein-based biosensors, spatiotemporal analysis of protein translation pathways, chemical control of protein translation, and light-responsive proteins.

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Developing next-generation inhibitors of SARSCoV2 protease

Rewiring cancer pathways to therapeutic activation

Engineering fluorescent proteins for electrical recording in the brain

Creating proteins that are intrinsically regulatable by light or drugs

Real-time visualization of biology in living cells and animals