The Lin Lab applies biochemical knowledge and engineering principles to the development of protein-based tools for molecular imaging, optogenetic studies, and gene therapy. Topics of investigation include fluorescent protein structures and biophysics, fluorescent protein-based biosensors, spatiotemporal analysis of protein translation pathways, chemical control of protein translation, and light-responsive proteins. Click on each image to learn more

Fluorescent protein engineering

Fluorescent reporters of fast electrical signals in the brain

Real-time control of protein activity by light or drugs

Real-time visualization of biology in living cells and animals

Protease engineering

Stable long-acting inhibitors of SARSCoV2 protease

Temporal integration of biochemical signals to detect and treat cancer