Michael Z. Lin, MD PhD

Laboratory of Intelligent Molecular Design

Because some things are better not left to chance

Departments of Neurobiology and Bioengineering at Stanford University

Our SARS-CoV-2 paper "An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations" is out in Science Translational Medicine! Congratulations to Michael Westberg, Yichi Su, Yan Wu, Xinzhi Zou, Chenzhou Hao, and our collaborators! Link for free full-text access

The Lin Lab applies chemical and physical principles to develop new methods to image and control biological processes. Current topics include genetically encoded voltage indicators, luciferase reporters of biochemical activity, single-chain optical and chemically controlled proteins, and small-molecule inhibitors of viral proteases.


Michael Z. Lin received an A.B. summa cum laude in Biochemistry (Harvard). After PhD training in biochemistry and neurobiology with Michael Greenberg at Harvard Medical School, Dr. Lin received his MD from UCLA, then performed postdoctoral research in protein engineering with Chemistry Nobel Laureate Roger Y. Tsien at UCSD. Dr. Lin is a recipient of a Burroughs Wellcome Career Award for Medical Scientists, a Rita Allen Scholar Award, a Damon Runyon-Rachleff Innovation Award, and a NIH Pioneer Award. Follow Dr. Lin at twitter.com/michaelzlin