Our paper "A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events" is out online in Neuron. We report a new voltage indicator, ASAP5 , that can detect 1mV transients, allowing us to follow dendritic voltage propagation following single synaptic vesicle transmission events. Congratulations to co-first authors Alex (Yukun) Hao and Sungmoo Lee, and our many amazing collaborators! Link for free full-text access until 2024/11/09 

The Lin Lab applies chemical and physical principles to develop new methods to image and control biological processes. Current topics include genetically encoded voltage indicators, luciferase reporters of biochemical activity, single-chain optical and chemically controlled proteins, and small-molecule inhibitors of viral proteases.

Michael Z. Lin received an A.B. summa cum laude in Biochemistry (Harvard). After PhD training in biochemistry and neurobiology with Michael Greenberg at Harvard Medical School, Dr. Lin received his MD from UCLA, then performed postdoctoral research in protein engineering with Chemistry Nobel Laureate Roger Y. Tsien at UCSD. Dr. Lin is a recipient of a Burroughs Wellcome Career Award for Medical Scientists, a Rita Allen Scholar Award, a Damon Runyon-Rachleff Innovation Award, and a NIH Pioneer Award. Follow Dr. Lin at twitter.com/michaelzlin